Therapeutic Drug Monitoring (TDM) is essential for drugs like methotrexate (MTX) that have a narrow therapeutic window. Lightnovo’s miniaturized Raman microscope provides an innovative solution for SERS mapping to enable accurate MTX quantification with improved limits of detection.
Key Highlights:
- Instrumentation: Measurements were conducted using Lightnovo’s miniaturized Raman microscope with SERS substrates.
- Enhanced Sensitivity: Achieved a Limit of Detection (LoD) of 3 μM and Limit of Quantification (LoQ) of 20 μM, surpassing previously reported results.
- SERS Mapping: MTX concentrations ranging from 0 to 75 μM were analyzed with a total measurement time of 15 minutes per chip, demonstrating the system’s speed and reliability.
Lightnovo’s miniRaman microscope delivers precise and efficient SERS mapping for therapeutic drug monitoring. This innovative technology is a valuable tool for researchers and clinicians, enabling better patient outcomes through accurate drug monitoring.
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