miniRaman microscope for Monitoring Methotrexate
Therapeutic Drug Monitoring (TDM) is essential for drugs like methotrexate (MTX) that have a narrow therapeutic window. Lightnovo’s miniaturized Raman microscope provides an innovative solution for SERS mapping to enable accurate MTX quantification with improved limits of detection.
Key Highlights:
- Instrumentation: Measurements were conducted using Lightnovo’s miniaturized Raman microscope with SERS substrates.
- Enhanced Sensitivity: Achieved a Limit of Detection (LoD) of 3 μM and Limit of Quantification (LoQ) of 20 μM, surpassing previously reported results.
- SERS Mapping: MTX concentrations ranging from 0 to 75 μM were analyzed with a total measurement time of 15 minutes per chip, demonstrating the system’s speed and reliability.
Conclusion:
Lightnovo’s miniRaman microscope delivers precise and efficient SERS mapping for therapeutic drug monitoring. This innovative technology is a valuable tool for researchers and clinicians, enabling better patient outcomes through accurate drug monitoring.